|
KMID : 0352519840210030049
|
|
Korea Univercity Medical Journal
1984 Volume.21 No. 3 p.49 ~ p.55
|
|
|
A study on the effect of garlic on the toxicity of phenylmercuric acetate in rats
|
|
朴在純/Park, Jai-Soon
車喆煥/Cha, Chul-Whan
|
|
|
Abstract
|
|
|
The garlic which is consumed as a daily spice in Korea contains abundant amounts of thiol compounds such as -SH and -S-S-radicals. These compounds have been thought to be involved in the detoxification mechanism of heavy metal poison by the formation of thiochelate compounds when reacting with heavy metals in the living body.
As part of an examination of this hypothesis, the effect of garlic on the detoxification mechanism of alkyl mercury poisoning in rats was studied.
The experimental rats were fed 6ppm of phenyl mercury in potable water in addition to 3 different concentrations of garlic in pellets (1.700, 3.350, and 6.700) which was compared with the control(no mercury and garlic) and the "garlic only" fed group (no mercury).
After rearing for 12 weeks with the above prescription, alkaline phosphatase activities in the blood and the accumulation of total mercury in the tissues of target organs of the brain, liver and kidney were measured.
To derive objective clues, additionally, histopathological changes in the tissues of the above organs were observed histologically.
As the result, it was found that components of garlic have some roles in detoxificating phenyl mercury poisoning such as decreasing alkaline phosphatase activity, increasing concentration of mercury in target organs, and inducing pathological damages to the organs.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|